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Flutivate cream is a topical corticosteroid.The use of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment.The active pharmaceutical ingredient is Fluticasone Propionate.Store Flutivate at room temperature away from moisture. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. Like other topical corticosteroids, it has anti-inflammatory, antipruritic, and vasoconstrictive properties. Apply the cream as soon as you remember.The possible side effects of Flutivate cream are stinging, burning, itching, irritation, dryness, or redness of the skin may occur when first applied to the skin. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. Arachidonic acid is released from membrane phospholipids by phospholipase A2.Apply a thin film of medication to the affected area and gently rub in, usually 1-2 times daily or as directed by your doctor. This should disappear in a few days.Flutivate cream is used for the treatment of eczema, psoriasis, allergies and rash. Manifestations of Cushing's syndrome, hyperglycemia, and glucosuria can also be produced in some patients by systemic absorption of topical corticosteroids while on treatment.
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