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Sibutramine is a medication that assists with weight loss by altering neurotransmitters within the brain. You should not take Sibutramine if you are allergic to Sibutramine, or if you have severe or uncontrolled high blood pressure, an eating disorder (anorexia or bulimia), if you are taking stimulant diet pills, or if you have a history of coronary artery disease, stroke, or heart disease.Before taking Sibutramine, tell your doctor if you have glaucoma, high blood pressure, liver or kidney disease, depression, underactive thyroid, seizures, a bleeding disorder, a history of gallstones, or if you are older than 65 or younger than 16.Side effects: dry mouth, upset stomach; changes in appetite; constipation, stomach pain; headache, back pain, joint pain; feeling nervous, dizzy, or depressed; flu symptoms, runny or stuffy nose, sore throat, cough; warmth, redness, or tingly feeling under your skin; trouble sleeping (insomnia); or mild skin rash. Tell your doctor if you do not lose at least 4 pounds after taking Sibutramine for 4 weeks along with a low calorie diet. Blocking the reuptake of neurotransmitters alters the balance of neurotransmitters within the nerve cells and thereby affect nerve function and interaction. Sibutramine blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin. Neurotransmitters are chemicals that are produced and released by nerves in order to communicate with other nerves.Do not use Sibutramine if you have taken an MAO inhibitor such as furazolidone, isocarboxazid, phenelzine, rasagiline, selegiline, or tranylcypromine in the last 14 days. Tell your doctor about all prescription and over-the-counter medications you use, especially antidepressants, cold or allergy medication, narcotic pain medicine, or migraine headache medicines. Serious, life threatening side effects can occur if you use Sibutramine before the MAO inhibitor has cleared from your body. Released neurotransmitters may attach to other nerves or they may be taken up again by the nerves that release them, a process termed reuptake.
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